Coronary Artery Disease and Acute Coronary Syndrome

Coronary Artery Disease and

Acute Coronary Syndrome

Coronary Artery Disease

        a subject of blood vessel disorder that is included in the full general category of atherosclerosis.

        The term atherosclerosis means fatty often and hard.

        It begins as soft deposits of fat that harden with grow and is often referred to as hardening of the arteries.

        The atheromas (fatty deposits) have a gustation for the coronary arteries.

Etiology and Patho

        Atherosclerosis is the major cause of CAD.

        Characterized by a focal deposit of cholesterol and lipids, primarily within the intimal wall of the artery.

        Plaque formation is the result of complex interactions amongst the components of the blood and elements forming the vascular wall.

        Endothelial lining can be altered as a result of chemical injuries much(prenominal) as hyperlipidemia or high-sheer stress, such as HTN.

         in that location is evidence that some viral and bacteria infections play a role in damaging endothelium by causing a local inflammatory response.

        C-reactive protein (CRP) is a non-specific marker of inflammation and is increase in patients with CAD.

        Chronic exposure to CRP triggers the rupture of plaque.

        With endothelium alteration, platelets ar activates and they waive a growth factor that stimulates smooth brawn proliferation that entraps lipids, which are calcified over time and form an irritant to the endothelium in which platelets nonplus and aggregate.

        Thrombin is generated and fibrin formation and thrombi occur.

        Endothelial replication is normal slow in adults, but in the presence of HTN & hyperlipidemia, increased cubicle turn-over lead to transient repeated denuding of the endothelium.

Developmental stages

CAD takes many years to develop.

When it becomes symptomatic, the sickness process is usually well advanced.

Stages of development are: fatty streak, raised fibrous plaque resulting from smooth muscle cellular phone proliferation and complicated lesion.

1)         Fatty streak

a.         Earliest lesion characterized by lipid-filled smooth muscle cells.

If you want to get a full essay, order it on our website: Ordercustompaper.com



If you want to get a full essay, wisit our page: write my paper