Haematology

Hematology and Oncology:Question 10
The correct answer is C
Educational Objectives
Recall the purpose of blood ray of light prior(prenominal) to transfusion.
Critique
The sole reason for blood irradiation is to keep on transfusion-related graft-versus-host disease (GVHD) in patient ofs at risk for it. Transfusion-related GVHD has a high gear mortality rate. Not only are the liver, skin, and gastrointestinal dodge under immunologic attack, tho the recipients bone marrow is as well destroyed by the donor T cells.
Gamma irradiation of cellular blood products interdicts transfusion-related GVHD by rendering donor T cells nonviable and incapable of mounting a GVHD response. The dose employ is between 25 and 50 Gy. Higher doses may interrupt with the function or survival of red cells and platelets. Leukocyte reduction is non sufficient for this purpose because it leaves behind too m all cells.
jibe at this dose has no effect on the transmittance of cytomegalovirus (or any pathogen), alloimmune sensitization, or leukocyte antigenicity. Although the cells are nonviable and provide not cause a sustained attack against the host, they notify still elaborate cytokine. Therefore, irradiation will not prevent febrile reactions. Irradiation has no effect on any of the mechanisms of transfusion-induced hemolysis.





Hematology and Oncology:Question 11
The correct answer is E
Educational Objectives
Select the appropriate timing for a work-up for a hereditary hypercoagulable state.
Critique
No testing is necessary; the patient should be started on anticoagulation therapy. Although her family history suggests that she has an underlying hereditary reproach predisposing to venous thromboembolism, it is unlikely that she has the factor V Leiden or factor II G2021 0A mutation because these abnormalities are not found in indigene Asian populations.
It is possible that she has a deficiency of protein C, protein 5, or antithrombin III, but it is not advisable to test for these abnormalities...If you want to get a full essay, order it on our website: Ordercustompaper.com



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